Combined therapies for cancer: a review of EGFR-targeted monotherapy and combination treatment with other drugs.

摘要: Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming thus interfere with processes tumorigenesis, progression and metastasis. The epidermal growth factor receptor (EGFR) was the first be proposed for targeted therapy, having been found commonly overexpressed in a range solid tumors play role cell proliferation, apoptosis, angiogenesis, invasion Despite successful development EGFR-targeted pharmacological agents, clinical molecular studies have indicated several limitations broad application this as monotherapy. Novel combination treatments might optimize effect EGFR inhibition have, therefore, investigated. Research conducted into mechanisms action synergy these is likely enhance target future treatment.