Evolution of the Structural Proteins of Human Immunodeficiency Virus: Selective Constraints on Nucleotide Substitution
作者： ANDREW LEIGH BROWN , PAULA MONAGHAN
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摘要: We have estimated the frequency of synonymous (KS) and amino acid replacement nucleotide substitutions (KA) among gag env genes published HIV sequences. The ratio KS to KA, can be used as an indicator intensity selective constraints on sequence a protein. By this approach we shown that for both gpl20 gp41, rate change in relative overall is higher than any other protein yet analyzed. proteins pl5 pl7 evolve slightly less rapidly, but p24 relatively strongly conserved. compared gene with those two retroviruses which appropriate data are available. In neither murine leukemia virus nor feline do envelope glycoproteins particularly rapidly. These results suggest unusual gp120 gp41 evolving under extremely weak rest th...
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