The molecular basis of adenovirus pathogenesis.

摘要: The pathology of type 5 (Ad5) pneumonia in Sigmodon hispidus cotton rats is closely similar to that humans. Virus replicates bronchiolar epithelial cells, but situ hybridization shows early gene expression macrophage/monocytes alveoli and hilar lymph nodes. Only required produce the which there an "early" a "late" phase. region 3 (E3), does not function viral replication, plays important role natural history at least subgroup C adenoviruses (types 1, 2, 5, 6), latent infections host-infected lymphocytes: 19-kDa glycoprotein markedly reduces transport class I MHC surface infected cells and, therefore, attack cytotoxic T could eliminate cells. When this mutated, late-phase inflammatory response infection increased. E3 14.7-kDa protein presence polymorphonuclear leukocytes early-phase pathological exudate. E1B 55-kDa essential effect late phase, when its inflammation greatly reduced although replication affected. Because only genes are induce complete pathogenesis adenovirus rats, it possible same lungs mice expressed.(ABSTRACT TRUNCATED AT 250 WORDS)