Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens

摘要: Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (−)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1—3 showed moderate activities with EC50 values 2.4×10−6, 2.6×10−6, 2.1×10−6 M, respectively. These compounds did not show selective toxicity P. falciparum test on mouse mammalian tumor cells, however, it is suggested that position methoxyl groups flavanone skeleton plays an important role activity.