Tyrosine phosphorylation of PICOT and its translocation to the nucleus in response of human T cells to oxidative stress.

摘要: Protein kinase C θ (PKCθ) is a Ca2+-independent isoform expressed in T but not B lymphocytes, and therefore suggested as being linked to the cell antigen receptor (TCR) function (1 2). PKCθ was shown an upstream regulator of critical transcription factors, such AP-1 NF-KB, activated lymphocytes (3). More recent studies demonstrated that colocalizes with TCR at core supramolecular activation complex (SMAC) formed contact region between antigen-responding cells antigen-presenting (APC) (4). Finally, PKCθ—deficient mice were found be impaired cell-mediated immune responses, apparently, due inability their triggered activate NF-κB factors (5).