Amino Acid Transport Studies in Brain Tumors

摘要: Amino acids are important biological substrates that play crucial roles in virtually all processes. These ionic nutrients serve not only as basic modules of proteins and hormones but also neurotransmitters, synaptic modulators, neurotransmitter precursors. Transfer amino across the hydrophobic domain plasma membrane is mediated by recognize, bind, transport them from extracellular medium into cell, or vice versa. In early 1960s different substrate-specific systems for mammalian cells were identified (Christensen 1990). General properties acid transporters revealed, such stereospecificity broad substrate specificity (i.e., several share same system). Functional criteria type (e.g., basic, acidic) thermodynamic (energy dependence transport) used to classify transporters. This functional classification has been retained date, since structural information on incomplete. The molecular identification related started 1990s, studies structure-function relationship genetics pathology associated with these gained considerable interest.