Biodistribution studies on L-3-[Fluorine-18]Fluoro-α-methyl tyrosine: A potential tumor-detecting agent

摘要: Iodine-123-α-methyl tyrosine has proven to be a promising SPECT agent for imaging amino acid uptake in tumors. We developed L-[3-18F]-α-methyl (FMT) PET studies. The aim of this study was investigate its potential use as tumor-detecting by using tumor-bearing mice. Methods: investigated the biodistribution normal BALB/C mice and BALB/cA nude bearing human rectal cancer cell line (LS180) until 120 min postinjection. FMT tumor at 60 postinjection with LS180 cancer, RPMI1788 B-cell lymphoma MCF7 mammary carcinoma assessed, results were compared 18F-fluoro-2-deoxy-D-glucose (FDG) uptake. effect competitive inhibition large neutral transport system unlabeled L-alanine also investigated. Results: amount blood fell 1.05%ID/20 g postinjection, whereas that pancreas 15.2%ID/20 g, resulting high pancreas-to-blood ratio 14.5. In other organs, initial peaked 5 then declined time. mice, peak observed postinjection.Tumor-to-blood tumor-to-muscle ratios ranged from 1.60 2.94 2.79 3.25 over 120-min observation period. Tumor clearly reduced system. tumors, significantly higher than FDG uptake, lymphoma, Tumor-to-blood LS180, 1.82, 5.88 3.56, respectively. Conclusion: FMT, like fluorinated acids, may become PET, assuming efficient methods radiosynthesis are developed.