Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio)

摘要: Domesticated animal populations often show profound reductions in predator avoidance and fear-related behavior compared to wild populations. These are remarkably consistent have been observed a diverse array of taxa including fish, birds, mammals. Experiments conducted common environments indicate that these behavioral differences genetic basis. In this study, we quantified between domesticated zebrafish strains used microarray analysis identify genes may be associated with variation. Compared zebrafish, spent more time near the water surface were likely occupy front aquarium nearest human observer. Microarray brain transcriptome identified high levels population variation gene expression, 1,749 significantly differentially expressed among Genes varied belonged functional categories included DNA repair, photolyase activity, response light stimulus, neuron development axon guidance, cell death, iron-binding, chromatin reorganization, homeobox genes. Comparatively fewer (112) differed notable gpr177 (wntless), selenoprotein P1a, synaptophysin synaptoporin, acyl-CoA binding domain containing proteins (acbd3 acbd4). large number underlie domestication. Comparisons similar studies domestication rainbow trout canids sixteen evolutionarily or functionally related represent components shared molecular mechanisms underlying convergent evolution during vertebrate However, conclusion must tempered by limitations comparisons low level population-level replication inherent studies.