Amino Acid Composition of Breast Milk from Urban Chinese Mothers

摘要: Human breast milk (BM) amino acid (AA) composition may be impacted by lactation stage or factors related to geographical location. The present cross-sectional study is aimed at assessing the temporal changes of BMAA over stages in a large cohort urban mothers China. Four hundred fifty BM samples, collected three Chinese cities covering eight months were analyzed for free (FAA) and total (TAA) AA o-phthalaldehyde/ fluorenylmethylchloroformate (OPA/FMOC) derivatization. Concentrations aligned with previous reports. Both sum individual TAA values significantly decreased during first periods then generally leveled off. Leucine methionine respectively most least abundant indispensable acids across all stages, whereas glutamic + glutamine (Glx) was cystine dispensable AA. contribution FAA levels less than 2%, except Glx, which FAA. In conclusion, from our comparable studies conducted other parts world, suggesting that this an evolutionary conserved trait largely independent geographical, ethnic, dietary factors.