VAB–4 combination chemotherapy in the treatment of metastatic testis tumors

摘要: Forty-two patients with advanced testis carcinoma without previous chemotherapy were treated VAB-4, and 41 evaluable. The program consisted of three in-hospital inductions 16 weeks apart, outpatient treatments every weeks. Of the patients, 80% achieved complete remissions (CR). Chemotherapy alone induced CR in 61%, partial (PR), 24% minor response (MR), 15%. An additional 20% (six PRs 2 MRs) following resection residual tumor deposits. With a median follow-up 27 months, duration has not been reached. those achieving to alone, 12% had relapses. Bulk extent metastatic disease, histology primary tumor, markers at beginning therapy influenced frequency CR. minimal 90% rate was 67% for thoracic disease 29% abdominal disease. Patients who embryonal no elevation alpha-fetoprotein higher CRs. Myelosuppression leukocyte count drop less than 1000/mm3 occurred patient chronic renal failure or pulmonary fibrosis. One died from sepsis while remission.