Effects of central lesions on disorders produced by multiple dorsal rhizotomy in rats

摘要: Abstract After multiple, bilateral, cervicothoracic dorsal rhizotomy from C5-T2, rats begin to chew certain areas of the denervated forelimbs. This abnormal chewing behavior is seen in both limbs within 1 mo after deafferentation. It persists for as long animals survive. Unilateral sciatic nerve section also leads a part region, but it does not occur all cases, area affected small and eventually stops. The simplest explanation this phenomenon that derives being rendered anesthetic analgesic. Alternatively, central changes produced by deafferentation may underlie behavior. To answer question, underwent simultaneous multiple bilateral one several unilateral spinal cord lesions. A hemisection or lesion lateral funiculus at C4 prevents limb ipsilateral lesion. quadrant, funiculus, tract Lissauer produces delay appearance limb. contralateral unaffected these These results demonstrate anesthesia analgesia only suggests middle ventral parts critical its prevention. hypothesized manifestation nervous system which lead some form dysesthesia experienced region.