Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
作者： J S Leeder , G L Kearns
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摘要: In a 2010 review in Clinical Pharmacology & Therapeutics, Nick Holford noted that neonates and young infants, maturation of the organs responsible for drug clearance is more important determinant pharmacokinetics (PK) than body size. 1 Here we recent developments provide new insights into how physiological environmental changes associated with adaptation to extrauterine life affect ontogeny biotransformation interpretation genotype–phenotype relationships newborns infants.
sci-hub.se 参考文章(5)
N Holford, Dosing in Children Clinical Pharmacology & Therapeutics. ,vol. 87, pp. 367- 370 ,(2010) , 10.1038/CLPT.2009.262
Robert M. Ward, Brinda Tammara, Sandra E. Sullivan, Dan L. Stewart, Natalie Rath, Xu Meng, Mary K. Maguire, Gail M. Comer, Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD) European Journal of Clinical Pharmacology. ,vol. 66, pp. 555- 561 ,(2010) , 10.1007/S00228-010-0811-8
A Mukherjee, T Dombi, B Wittke, R Lalonde, Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period Clinical Pharmacology & Therapeutics. ,vol. 85, pp. 56- 63 ,(2009) , 10.1038/CLPT.2008.177
M J Blake, A Gaedigk, R E Pearce, L R Bomgaars, M L Christensen, C Stowe, L P James, J T Wilson, G L Kearns, J S Leeder, Ontogeny of Dextromethorphan O‐ and N‐demethylation in the First Year of Life Clinical Pharmacology & Therapeutics. ,vol. 81, pp. 510- 516 ,(2007) , 10.1038/SJ.CLPT.6100101
C. L. Johnson, J. Versalovic, The Human Microbiome and Its Potential Importance to Pediatrics Pediatrics. ,vol. 129, pp. 950- 960 ,(2012) , 10.1542/PEDS.2011-2736