Coffee consumption and the risk of primary liver cancer: Pooled analysis of two prospective studies in Japan
作者： Taichi Shimazu , Yoshitaka Tsubono , Shinichi Kuriyama , Kaori Ohmori , Yayoi Koizumi
DOI: 10.1002/IJC.20989
关键词:
摘要: Although case-control studies suggested that coffee consumption is associated with a decreased risk of liver cancer, no prospective cohort study has been carried out. To examine the association between and we conducted pooled analysis data available from 2 in Japan. A self-administered questionnaire about frequency other health habits was distributed to 22,404 subjects (10,588 men 11,816 women) Cohort 1 38,703 (18,869 19,834 2, aged 40 years or more, previous history cancer. We identified 70 47 cases cancer among (9 follow-up 170,640 person-years) (7 284,948 person-years), respectively. used Cox proportional hazards regression estimate relative (RR) 95% confidence interval (CI) incidence. After adjustment for potential confounders, RR (95% CI) drinking never, occasionally more cups/day were 1.00 (Reference), 0.71 (0.46-1.09) 0.58 (0.36-0.96), respectively (p trend = 0.024). In subgroup disease, found significant inverse Our findings support hypothesis decreases Further investigate role prevention high-risk population are needed.
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