The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice.

摘要: After injury to the substantia nigra pars compacta (SNpc), remaining neurons sprout ensure normal dopamine delivery striatum. The consequent striatal reinnervation is highly regulated, with cells sprouting so that density of terminals returns normal. Sprouting as a result accompanied by strong glial response; however, it difficult know whether this response or aiding in sprouting. two cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are important modulators glia response. This study demonstrates their role regulating dopaminergic associated means examine was induced 6-hydroxydopamine lesions SNpc haloperidol treatment (in absence injury). In wild-type animals, association microglial astrocyte proliferation followed partial treatment. Neither evoked type I IL-1 receptor-deficient mice, whereas IL-6-deficient both treatments resulted but not We conclude plays modulating thereby guidance trophic factors for new fibers, IL-6 may be triggering outgrowth fibers. these play an plasticity regeneration separate from inflammatory brain injury.