Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects.

摘要: OBJECTIVE: To determine whether the evening intake of 5 mg melatonin affects 24 h arterial blood pressure and heart-rate profiles. METHODS: Twenty-one young normotensive subjects were administered placebo or for 4 weeks, according to a cross-over double-blind design, subjected ambulatory monitoring on first last days each treatment period. RESULTS: The chronic caused decrease in systolic throughout period (109.1+/- 7.2 versus 113.6 +/- 8.15 mmHg, P < 0.05), diastolic (by 6.4 0.05) limited second half night, slight lowering heart rate during diurnal hours (78.6 7.6 81.5 10.1 beats/min, an acceleration similar degree night. hypotensive action may be explained theoretically terms various complex synergistic mechanisms that so far have been verified only experimental studies animals. etiology nocturnal remains unknoiwn. Further controlled are needed order better understand cardiovascular effects evaluate possible pharmacologic interactions. CONCLUSION: