Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies
作者： B S Gluskin , B J Mickey
DOI: 10.1038/TP.2016.22
关键词:
摘要: The D2 dopamine receptor mediates neuropsychiatric symptoms and is a target of pharmacotherapy. Inter-individual variation density thought to influence disease risk pharmacological response. Numerous molecular imaging studies have tested whether common genetic variants binding potential (BP) in humans, but demonstration robust effects has been limited by small sample sizes. We performed systematic search published human vivo estimate effect sizes on striatal BP. identified 21 examining 19 11 genes. most commonly studied variant was single-nucleotide polymorphism ANKK1 (rs1800497, Glu713Lys, also called ‘Taq1A'). Fixed- random-effects meta-analyses this (5 studies, 194 subjects total) revealed that BP significantly robustly lower among carriers the minor allele (Lys713) relative major homozygotes. weighted standardized mean difference −0.57 under fixed-effect model (95% confidence interval=(−0.87, −0.27), P=0.0002). normal relationship between rs1800497 not apparent with diseases. Significant associations baseline reported for four DRD2 (rs1079597, rs1076560, rs6277 rs1799732) PER2 repeat polymorphism, none yet more than two independent samples. Our findings resolve discrepancies literature establish influences availability. This likely contribute important individual differences function,
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