Human Immunodeficiency Virus (HIV) Type 1 Strain MN Neutralizing Antibody in HIV-Infected Children: Correlation with Clinical Status and Prognostic Value

摘要: Protective immunity to human immunodeficiency virus (HIV) was examined in 228 serial sera from 58 HIV-infected children before and during antiretroviral therapy. Binding antibodies putative protective V3 epitopes of HIV-1IIIB HIV-1MN were investigated by a peptide ELISA, neutralizing inhibition cell-free viral infection. No difference binding total IgG or subclasses observed between patients with mild (group A) advanced disease B). However, group A more likely possess antibody titers > = 225 (P .040 after adjustment for CD4). This threshold titer also predicted clinical outcome age-adjusted CD4 count 10% normal median. Patients .0028). Epitopes other than the linear loop contribute this immune response. Identification these should assist therapy AIDS HIV vaccine development.