Lack of association between maternal antibodies to V3 loop peptides and maternal-infant HIV-1 transmission

摘要: The association between maternal antibodies to HIV-1 peptides in pregnant women and the acquisition of infection by their offspring was investigated. Pregnant infected Haitian were tested for presence against 14-17 amino acid length from V3 loop region strains IIIb MN. Antibody testing performed 2 separate laboratories enzyme-linked immunosorbent assay (ELISA). Peptides 4 regions synthesized several different purity confirmed high performance liquid chromatography. mothers infants who acquired did not differ significantly uninfected prevalence or concentration any 15 evaluated. Additional studies are indicated determine if neutralizing other immunologic parameters associated with maternal-infant transmission. (authors)