Molecular Mechanisms of HIV-1 Vertical Transmission and Pathogenesis in Infants
作者： Nafees Ahmad
DOI: 10.1016/S1054-3589(07)56015-1
关键词:
摘要: Publisher Summary This chapter presents data on the molecular and biological aspects of human immunodeficiency virus-1 (HIV‐1) vertical transmission mechanisms HIV‐1 pathogenesis in infants. Progress has been made understanding infected Several maternal factors including advanced clinical stages, low CD4+ lymphocyte counts, high viral load, immune response, disease progression have implicated an increased risk transmission. While use antiretroviral therapy (ART) during pregnancy shown to reduce mother‐to‐infant transmission, selective ART‐resistant mutants also documented. HIV‐1‐infected neonates infants develop symptomatic acquired deficiency syndrome (AIDS) more rapidly than adults, their own mothers do. By using HIV‐1‐ mother–infant pairs as a transmitter-recipient model minor genotype s with R5 phenotypes found were transmitted initially maintained same properties.
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