The endocannabinoid system in the amygdala and modulation of fear.

摘要: Posttraumatic stress disorder (PTSD) is a persistent, trauma induced psychiatric condition characterized by lifelong complex cognitive, emotional and behavioral phenotype. Although many individuals that experience are able to gradually diminish their responding trauma-related stimuli over time, known as extinction learning, suffering from PTSD impaired in this capacity. An inability decline initially normal adaptive fear response, can be confronted with exposure-based therapies, often combination pharmacological treatments. Due the complexity of PTSD, currently available pharmacotherapeutics inadequate treating deficient observed patients. To develop novel therapeutics, researchers have exploited conserved nature stress-associated responses neurocircuits across species an attempt translate knowledge gained preclinical studies into clinic. There growing evidence on endocannabinoid modulation due 'on demand' synthesis degradation. Involvement endocannabinoids makes system very attractive for finding effective therapeutics related disorders. In review, brief introduction neuroanatomy circuitry will provided model study PTSD. Then, discussed important component modulation. regard, anandamide degrading enzyme, fatty acid amide hydrolase (FAAH) exemplified target identified validated strongly clinical translational enhancing extinction.