Progesterone and DNA Damage Encourage Uterine Cell Proliferation and Decidualization through Up-regulating Ribonucleotide Reductase 2 Expression during Early Pregnancy in Mice

摘要: Embryo implantation into the maternal uterus is a crucial step for successful establishment of mammalian pregnancy. Following attachment embryo to uterine luminal epithelium, stromal cells undergo steroid hormone-dependent decidualization, which characterized by cell proliferation and differentiation. The mechanisms underlying hormone-induced differentiation during decidualization are still poorly understood. Ribonucleotide reductase, consisting two subunits (RRM1 RRM2), rate-limiting enzyme in deoxynucleotide production DNA synthesis plays an important role tumorgenicity. Based on our microarray analysis, Rrm2 expression was significantly higher at sites compared with interimplantation mouse uterus. However, expression, regulation, function RRM2 unknown. Here we show that although both RRM1 markedly induced undergoing only regulated progesterone, key regulator decidualization. Further studies showed induction progesterone mediated AKT/c-MYC pathway. can also be replication stress damage through ATR/ATM-CHK1-E2F1 weight deciduoma effectively reduced specific inhibitors RRM2. decidual/trophoblast prolactin-related protein (Dtprp), reliable marker mice, steroid-induced decidual after HU treatment. Therefore, may effector signaling induce