Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases.

作者: Hyojin Kim , Xianhua Xu , Seol-Bong Yoo , Ping-Li Sun , Yan Jin

DOI: 10.1111/J.1365-2559.2012.04356.X

关键词:

摘要: Aims:  The anaplastic lymphoma kinase gene (ALK) has attracted considerable attention as a potential molecular target in non-small-cell lung cancer (NSCLC). However, it is unclear whether ALK alterations are acquired during the metastatic progression of NSCLC. Methods and results:  status expression were evaluated series 67 primary NSCLCs their corresponding lesions using fluorescence in-situ hybridization immunohistochemistry. rearrangement was detected 7.5% (5/67) tumours 9.0% (6/67) metastases (P < 0.001). copy number gain (CNG) 1.5% (1/67) 35.8% (24/67) metastases. Whereas only adenocarcinomas, CNG identified various histological subtypes NSCLC. 11.9% (8/67) 25.4% (17/67) lesions. Conclusions:  alteration can be NSCLC, associated with expression.

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