Bone evaluation in paediatric chronic kidney disease: clinical practice points from the European Society for Paediatric Nephrology CKD-MBD and Dialysis working groups and CKD-MBD working group of the ERA-EDTA.

摘要: Mineral and bone disorder (MBD) is widely prevalent in children with chronic kidney disease (CKD) associated significant morbidity. CKD may cause disturbances remodelling/modelling, which are more pronounced the growing skeleton, manifesting as short stature, pain deformities, fractures, slipped epiphyses ectopic calcifications. Although assessment of health a key element clinical care CKD, it remains major challenge for physicians. On one hand, biopsy histomorphometry gold standard assessing health, but expensive, invasive requires expertise interpretation histology. other currently available non-invasive measures, including dual-energy X-ray absorptiometry biomarkers formation/resorption, affected by growth pubertal status have limited sensitivity specificity predicting changes turnover mineralization. In absence high-quality evidence, there wide variations practice diagnosis management CKD-MBD childhood. We present points (CPPs) on Stages 2-5 dialysis based best evidence consensus experts from Dialysis working groups European Society Paediatric Nephrology group Renal Association-European Transplant Association. These CPPs should be carefully considered treating physicians adapted to individual patients' needs appropriate. Further areas research suggested.