摘要: Publisher Summary This chapter focuses on the mechanisms by which internal structure of mature myofibril is specified and maintained. One most remarkable features muscle great precision with specified. The properties giant proteins titin nebulin. In case titin, molecule parallel (or almost so) to long axis myofibril, so molecular length must increase as sarcomere increases. Nebulin was identified large-pore polyacrylamide gels at same time initially designated a third component titin. Molecules both these are approximately 1 μm that they arranged thick thin filaments in situ . Both molecules span half therefore position influence accurate assembly maintenance over what are, terms, very large distances.
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