Coactivation of STAT and Ras Is Required for Germ Cell Proliferation and Invasive Migration in Drosophila

摘要: Primordial germ cells (PGCs) undergo proliferation, invasion, guided migration, and aggregation to form the gonad. Here we show that in Drosophila, receptor tyrosine kinase Torso activates both STAT Ras during early phase of PGC development, coactivation is required for proliferation invasive migration. Embryos mutant stat92E or Ras1 have fewer PGCs, these migrate slowly, errantly, fail coalesce. Conversely, overactivation molecules causes supernumerary their premature transit through gut epithelium, ectopic colonization. A requirement RTK Drosophila development analogous mouse, which c-kit required, suggesting a conserved molecular mechanism governing behavior flies mammals.