Survival after radical prostatectomy for clinically localised prostate cancer: a population-based study

摘要: Objectives To describe survival and cause of death in a nationwide cohort Danish patients with prostate cancer undergoing radical prostatectomy (RP). To risk factors associated mortality. Patients Methods Observational study 6489 men localised treated RP at six different hospitals Denmark between 1995 2011. Survival was described using Kaplan–Meier estimates. Causes were obtained from the national registry cross-checked patient files. Cumulative incidence death, any cancer-specific, Nelson–Aalen estimates. Risk for analysed Cox multivariate regression model covariates: age, cT-category, PSA level biopsy Gleason score. Results The median follow-up 4 years. During follow-up, 328 died, 109 (33.2%) 219 (66.8%) other causes. Six (0.09%) died ≤30 days RP. In analysis, cT-category predictor (P < 0.001). Compared T1 disease, both cT2c (hazard ratio [HR] 2.2) cT3 (HR 7.2) significantly increased death. For every doubling by 34.8% Biopsy score + 3 ≥8 an compared ≤ 6 2.3 2.7 = 0.003), respectively. The cumulative hazard all-cause cancer-specific mortality after 10 years 15.4% (95% confide3nce interval [CI] 13.2–17.7) 6.6% CI 4.9–8.2) respectively. Conclusions We present first analysis complete, cancer. The main limitation relatively short follow-up. Interestingly, our results are comparable to high-volume, single institution, surgeon series.