Protein Tyrosine Kinase 7 (PTK7) as a Predictor of Lymph Node Metastases and a Novel Prognostic Biomarker in Patients with Prostate Cancer
作者： Hongtuan Zhang , Andi Wang , Shiyong Qi , Shang Cheng , Bing Yao
关键词: Oncology 、 Prostate cancer 、 PCA3 、 Cancer research 、 Internal medicine 、 Immunohistochemistry 、 Biochemical recurrence 、 Lymph node 、 Reverse transcription polymerase chain reaction 、 Cancer 、 Tyrosine kinase 、 Medicine
摘要: Protein tyrosine kinase 7 (PTK7) has been studied in various tumors, but its role prostate cancer remains unknown. This study is aimed to investigate the prognostic and predictive significance of PTK7 patients with cancer. expression was evaluated by real-time reverse transcription polymerase chain reaction (RT-PCR) Western blot analysis 20 pairs benign prostatic hyperplasia specimens specimens. Then, we examined immunohistochemical 180 clinical significances. Elevated significantly associated lymph node metastases, seminal vesicle invasion, stage, higher preoperative prostate-specific antigen, Gleason score, angiolymphatic biochemical recurrence. The results revealed that overexpression an independent factor for poor overall survival recurrence-free survival. present data provide evidence predicts metastasis survival, highlighting potential function as a therapeutic target
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Martin Andreas Røder, Klaus Brasso, Ib Jarle Christensen, Jørgen Johansen, Niels Christian Langkilde, Helle Hvarness, Steen Carlsson, Henrik Jakobsen, Michael Borre, Peter Iversen, Survival after radical prostatectomy for clinically localised prostate cancer: a population-based study BJUI. ,vol. 113, pp. 541- 547 ,(2014) , 10.1111/BJU.12065
Kristin L Whitford, Anirvan Ghosh, Plexin Signaling via Off-Track and Rho Family GTPases Neuron. ,vol. 32, pp. 1- 3 ,(2001) , 10.1016/S0896-6273(01)00459-7
Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Masanori Yabuki, Koichiro Harada, Masatsugu Hori, Hitoshi Kikutani, Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling Nature Cell Biology. ,vol. 6, pp. 1204- 1211 ,(2004) , 10.1038/NCB1193
Anne-Catherine Lhoumeau, Francesca Puppo, Thomas Prébet, Laurent Kodjabachian, Jean-Paul Borg, PTK7: a cell polarity receptor with multiple facets. Cell Cycle. ,vol. 10, pp. 1233- 1236 ,(2011) , 10.4161/CC.10.8.15368
Alberto Briganti, R. Jeffrey Karnes, Luigi Filippo Da Pozzo, Cesare Cozzarini, Umberto Capitanio, Andrea Gallina, Nazareno Suardi, Marco Bianchi, Manuela Tutolo, Andrea Salonia, Nadia Di Muzio, Patrizio Rigatti, Francesco Montorsi, Michael Blute, Combination of Adjuvant Hormonal and Radiation Therapy Significantly Prolongs Survival of Patients With pT2–4 pN+ Prostate Cancer: Results of a Matched Analysis European Urology. ,vol. 59, pp. 832- 840 ,(2011) , 10.1016/J.EURURO.2011.02.024
Thomas Prebet, Anne-Catherine Lhoumeau, Christine Arnoulet, Anaïs Aulas, Sylvie Marchetto, Stéphane Audebert, Francesca Puppo, Christian Chabannon, Danielle Sainty, Marie-Josée Santoni, Michael Sebbagh, Virginia Summerour, Yannick Huon, Won-Sik Shin, Seung-Taek Lee, Benjamin Esterni, Norbert Vey, Jean-Paul Borg, None, The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome Blood. ,vol. 116, pp. 2315- 2323 ,(2010) , 10.1182/BLOOD-2010-01-262352
Won-Sik Shin, Yong-Sun Maeng, Jae-Won Jung, Jeong-Ki Min, Young-Guen Kwon, Seung-Taek Lee, Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis Biochemical and Biophysical Research Communications. ,vol. 371, pp. 793- 798 ,(2008) , 10.1016/J.BBRC.2008.04.168
Peter Wehner, Iryna Shnitsar, Henning Urlaub, Annette Borchers, RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure Development. ,vol. 138, pp. 1321- 1327 ,(2011) , 10.1242/DEV.056291
Ling Meng, Kwame Sefah, Meghan B. O'Donoghue, Guizhi Zhu, Dihua Shangguan, Afshan Noorali, Yan Chen, Lei Zhou, Weihong Tan, Silencing of PTK7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis via Mitochondrial Pathway PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0014018
Kylie L. Gorringe, Alex Boussioutas, David D. L. Bowtell, , , Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes, Chromosomes and Cancer. ,vol. 42, pp. 247- 259 ,(2005) , 10.1002/GCC.20136