A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer.

作者: Martin Schuler , Christoph Rochlitz , Jo Ann Horowitz , Jens Schlegel , André P. Perruchoud

DOI: 10.1089/HUM.1998.9.14-2075

关键词:

摘要: … Schuler et al. report on a phase I clinical study of local y/t p53 In addition, clinical effects suggestive of a moderate local angene therapy in patients with advanced non-small cell lung …

参考文章(32)
K N Wills, M P Harris, W Hancock, S Sutjipto, R J Gregory, H M Shepard, D E Johnson, D C Maneval, D Cornell, Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein. Cancer Gene Therapy. ,vol. 3, pp. 121- 130 ,(1996)
J Bártková, B Vojtĕsek, J Lukás, J Bártek, D P Lane, C A Midgley, A Rejthar, Z Stasková, J Kovarík, J V Gannon, Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene. ,vol. 6, pp. 1699- 1703 ,(1991)
Elizabeth A. Grimm, Toshiyoshi Fujiwara, Laurie B. Owen-Schaub, Jack A. Roth, De Wei Cai, Tapas Mukhopadhyay, A Retroviral Wild-type p53 Expression Vector Penetrates Human Lung Cancer Spheroids and Inhibits Growth by Inducing Apoptosis Cancer Research. ,vol. 53, pp. 4129- 4133 ,(1993)
B. Smith-Sørensen, Eivind Hovig, M. S. Greenblatt, Therese Sorlie, R. Montesano, M. Hollstein, C. C. Harris, K. Rice, R. Fuchs, T. Soussi, Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Research. ,vol. 22, pp. 3551- 3555 ,(1994)
Bernard G. Huyghe, Xiaodong Liu, Suganto Sutjipto, Barry J. Sugarman, Mark T. Horn, H. Michael Shepard, Carl J. Scandella, Paul Shabram, Purification of a Type 5 Recombinant Adenovirus Encoding Human p53 by Column Chromatography Human Gene Therapy. ,vol. 6, pp. 1403- 1416 ,(1995) , 10.1089/HUM.1995.6.11-1403
T. Fujiwara, D. W. Cai, R. N. Georges, T. Mukhopadhyay, E. A. Grimm, J. A. Roth, Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model Journal of the National Cancer Institute. ,vol. 86, pp. 1458- 1462 ,(1994) , 10.1093/JNCI/86.19.1458
Scott W. Lowe, H.Earl Ruley, Tyler Jacks, David E. Housman, p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell. ,vol. 74, pp. 957- 967 ,(1993) , 10.1016/0092-8674(93)90719-7
Ken N. Wills, Daniel C. Maneval, Patricia Menzel, Matthew P. Harris, Suganto Sutjipto, Mei-Ting Vaillancourt, Whei-Mei Huang, Duane E. Johnson, Scott C. Anderson, Shu Fen Wen, Robert Bookstein, H. Michael Shepard, Richard J. Gregory, Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Human Gene Therapy. ,vol. 5, pp. 1079- 1088 ,(1994) , 10.1089/HUM.1994.5.9-1079
JA Roth, D Nguyen, DD Lawrence, BL Kemp, CH Carrasco, DZ Ferson, WK Hong, R Komaki, JJ Lee, JC Nesbitt, KMW Pisters, JB Putnam, R Schea, DM Shin, GL Walsh, MM Dolormente, C-I Han, FD Martin, N Yen, K Xu, LC Stephens, TJ McDonnell, T Mukhopadhyay, D Cai, None, Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Medicine. ,vol. 2, pp. 985- 991 ,(1996) , 10.1038/NM0996-985