Pharmacogenetic application in personalized cancer treatment.

摘要: Pharmacogenetic is broadly understood as study or clinical testing of genetic variations that contribute to differing response drugs. In cancer treatment, applications pharmacogenetic cover three areas: avoidance adverse drug reaction (ADR), selection treatment options, and prediction recurrence. Patients with in UGT1A1 DPYD genes are hypersensitive Irinotecan 5-Fluorouracil (5FU) respectively. Therefore, the chance for patients suffer from ADR using those drugs can be predicted a priori by simple tests. Secondly, efficacy targeted therapy such Cetuximab Erlotinib, non- agents temozolomide nitrosourea has been influenced presence certain epigenetic markers tumors. Lastly, microarray analysis evaluate 70-gene expression profile breast samples shown recent studies predict probability whose tumors have determined low score based on gene may omit chemotherapy altogether, avoiding unnecessary therapeutic side effects. summary, tests help patients, their caregivers, doctors deciding best options favorable success, well saving overall costs.