Inflammatory cutaneous adverse effects of methylene blue dye injection for lymphatic mapping/sentinel lymphadenectomy.

摘要: Background Methylene blue (MB) dye has been used for lymphatic mapping/sentinel lymphadenectomy (LM/SL) in staging of melanoma and breast cancer. It noted to cause skin necrosis, but its more mild adverse effects from intraparenchymal injections are not well characterized. Methods Patients undergoing LM/SL cancer were reviewed, with attention devoted manifestations. Patients mastectomies excluded rule out changes flap devascularization. All patients injected intraparenchymally. Results Ninety-five underwent MB injection during a nationwide shortage lymphazurin; 78 17 melanoma, 51 conservation (BCT). There was no frank necrosis among any the patients. Six (11.8%) BCT demonstrated inflammatory changes. Four developed findings indistinguishable infectious cellulitis, two developing telangiectasias prior radiotherapy. Two had fat confirmed at site away surgical site; one on imaging by biopsy. Most symptoms resolved after conservative management. Conclusions MB may cutaneous subtle than previously described. Physicians caring having using should be aware these so that proper differential diagnosis can entertained postoperatively. J. Surg. Oncol. 2009;99:356–360. © 2009 Wiley-Liss, Inc.