The use of antidepressants in bipolar disorder patients with depression

摘要: Introduction: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psychosocial impairment elevated risk suicide, is significantly greater than the spent in manic/hypomanic forms disorders. Yet, manic states have been focus interest most research over past quarter century. Not a single antidepressant approved for treatment major disorder, as monotherapy, has received regulatory approval depression despite their common use depression.Areas covered: We reviewed randomized studies, particularly ones initially intended registration purposes, systematic guidelines, development this guide to decision implementation interventions disorders.Expert opinion: Expert Opinion section emphasizes strategies, not individual agents. efficacious performance mood s...