Gadolinium-Enhanced Susceptibility-Weighted Imaging in Multiple Sclerosis: Optimizing the Recognition of Active Plaques for Different MR Imaging Sequences

摘要: BACKGROUND AND PURPOSE: Gadolinium SWI is MR imaging that has recently been reported to be effective in the evaluation of several neurologic disorders, including demyelinating diseases. Our aim was analyze accuracy gadolinium for detecting evidence active inflammation on MS plaques when a BBB dysfunction demonstrated by focal gadolinium-enhanced lesion and compare this technique with T1 spin-echo magnetization transfer contrast. MATERIALS METHODS: studies 103 patients (170 examinations) were performed using 1.5T scanner. Two neuroradiologists scrutinized signal abnormalities compared them before after an additional pulse. Interrater agreement evaluated among contrast, SWI, κ coefficient. The contrast sequence adopted as criterion standard cohort. Thus, sensitivity, specificity, positive predictive value, negative value calculated sequences. RESULTS: Differences evident spin-echo, highest number plaques. highly correlated depicting acute (κ coefficient = 0.860; sensitivity 0.837), these techniques provided better performance 0.78; 0.645). CONCLUSIONS: able detect had than spin-echo. Increasing applications clinical practice can improve our knowledge MS, likely allowing addition analysis striking findings previously central vein sign.