Direct Synthesis of Peptide-Containing Silicones: A New Way to Bioactive Materials.
作者： Julie Martin , Mohammad Wehbi , Cécile Echalier , Sylvie Hunger , Audrey Bethry
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摘要: A simple and efficient way to synthesize peptide-containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid-catalyzed copolymerization dichlorodimethylsilane, hybrid dichloromethyl peptidosilane, Si(vinyl)- or SiH-functionalized monomers. Functionalized first obtained then, after hydrosilylation cross-linking, polydimethylsiloxane (PDMS)-based straightforwardly obtained. The introduction an antibacterial yielded PDMS showing activity against Staphylococcus aureus. RGD ligands showed improved cell-adhesion properties. This generic method was fully compatible with the stability peptides thus opened synthesis wide range biologically active silicones.
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