The early inflammatory response after flexor tendon healing: A gene expression and histological analysis

摘要: Despite advances in surgical techniques over the past three decades, tendon repairs remain prone to poor clinical outcomes. Previous attempts improve healing have focused on later stages of (i.e., proliferation and matrix synthesis). The early inflammatory phase healing, however, is not fully understood its modulation during has yet been studied. Therefore, purpose this work was characterize flexor with goal identifying inflammation-related targets for future treatments. Canine tendons were transected repaired using identical those used clinically. response monitored 9 days. Temporal changes immune cell populations gene expression inflammation-, degradation-, extracellular matrix-related factors examined. Gene patterns paralleled repair-site populations. Of observed changes, most dramatic effect a greater than 4,000-fold up-regulation pro-inflammatory factor IL-1β. While an likely necessary occur, high levels cytokines may result collateral tissue damage impaired healing. These findings suggest that treatment approaches consider