Distribution and Properties of Functional Postsynaptic Kainate Receptors on Neocortical Layer V Pyramidal Neurons
作者： Matthias Eder , Klaus Becker , Gerhard Rammes , Anja Schierloh , Shahnaz Christina Azad
DOI: 10.1523/JNEUROSCI.23-16-06660.2003
关键词:
摘要: The distribution of glutamate receptor subtypes on the surface neurons is highly relevant for synaptic transmission and signal processing. In present study we investigated location properties functional kainate receptors (KARs) somatodendritic membrane rat neocortical layer V pyramidal neurons. Infrared-guided laser stimulation was used to apply photolytically soma various sites along apical dendrite. Electrical currents, resulting from activation pharmacologically isolated KARs, were measured by whole-cell patch-clamp recording. addition, KARs somatic dendritic outside-out patches activated while still within brain tissue. We found that are located entire examined. Fast kinetics, a linear I-V relationship, relatively high single-channel conductance characteristic features these receptors. provide evidence unitary identical. Regarding subcellular our results indicate density increases toward distal They mainly at extrasynaptic but also mediate fast signaling triggered afferent stimulation. differential speaks in favor selective targeting central may reflect mechanism location-dependent regulation efficacy. Furthermore, it feasible assume could be "spillover" synaptically released glutamate, ambient CSF, or adjacent astrocytes.
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Alan Peters, Number of Neurons and Synapses in Primary Visual Cortex Springer, Boston, MA. pp. 267- 294 ,(1987) , 10.1007/978-1-4615-6616-8_7
GW Huntley, SW Rogers, T Moran, W Janssen, N Archin, JC Vickers, K Cauley, SF Heinemann, JH Morrison, Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7 The Journal of Neuroscience. ,vol. 13, pp. 2965- 2981 ,(1993) , 10.1523/JNEUROSCI.13-07-02965.1993
Paola Bezzi, Maria Domercq, Liliana Brambilla, Rossella Galli, Dominique Schols, Erik De Clercq, Angelo Vescovi, Giacinto Bagetta, George Kollias, Jacopo Meldolesi, Andrea Volterra, CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity Nature Neuroscience. ,vol. 4, pp. 702- 710 ,(2001) , 10.1038/89490
Jeffrey C. Magee, Erik P. Cook, Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature Neuroscience. ,vol. 3, pp. 895- 903 ,(2000) , 10.1038/78800
Mark Mayer, KAINATE RECEPTORS : FINDING HOMES AT SYNAPSES Nature. ,vol. 389, pp. 542- 543 ,(1997) , 10.1038/39177
Ingrid Bureau, Serge Bischoff, Steve F. Heinemann, Christophe Mulle, Kainate Receptor-Mediated Responses in the CA1 Field of Wild-Type and GluR6-Deficient Mice The Journal of Neuroscience. ,vol. 19, pp. 653- 663 ,(1999) , 10.1523/JNEUROSCI.19-02-00653.1999
Pablo E. Castillo, Robert C. Malenka, Roger A. Nicoll, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons Nature. ,vol. 388, pp. 182- 186 ,(1997) , 10.1038/40645
Matthias Eder, Walter Zieglgänsberger, Hans-Ulrich Dodt, Neocortical Long-Term Potentiation and Long-Term Depression: Site of Expression Investigated by Infrared-Guided Laser Stimulation The Journal of Neuroscience. ,vol. 22, pp. 7558- 7568 ,(2002) , 10.1523/JNEUROSCI.22-17-07558.2002
Christophe Mulle, Andreas Sailer, Isabel Pérez-Otaño, Heather Dickinson-Anson, Pablo E Castillo, Ingrid Bureau, Cornelia Maron, Fred H Gage, Jeffrey R Mann, Bernhard Bettler, Stephen F Heinemann, None, Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice Nature. ,vol. 392, pp. 601- 605 ,(1998) , 10.1038/33408
Paola Bezzi, Giorgio Carmignoto, Lucia Pasti, Sabino Vesce, Daniela Rossi, Barbara Lodi Rizzini, Tullio Pozzan, Andrea Volterra, Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. ,vol. 391, pp. 281- 285 ,(1998) , 10.1038/34651