Decoding the Ascaris suum Genome using Massively Parallel Sequencing and Advanced Bioinformatic Methods - Unprecedented Prospects for Fundamental and Applied Research

摘要: Parasitic nematodes cause substantial morbidity and mortality in animals people globally major losses to food production annually. Ascaris is among the commonest geohelminths of swine worldwide, causes disease socioeconomic losses, particularly developing countries. The control ascariasis has become a global health welfare priority, but current treatment programs carry significant risk inducing anthelmintic resistance. Therefore, there need work toward sustainable Ascaris/ascariasis, built on solid understanding its molecular biology genetics. Recently, we reported 273 megabase (Mb) draft genome suum (sequenced from reproductive tract single adult female worm) explored transcription different organs, stages, both sexes this nematode using advanced sequencing computer technologies. We characterized key genes biological pathways linked parasite's migration host, immunobiology, reproduction, development. also predicted prioritized drug targets A. suum, providing basis for discovering new groups nematocides. present chapter provides an account these recent advances, describes methodologies established, emphasizes prospects profound investigations into comparative genomics, genetics, evolution, epidemiology, ecology pig human hosts as well development interventions against other helminthiases. © 2013 Copyright