Blood-Coagulation Factor VIII: Genetics, Physiological Control, and Bioassay

摘要: Publisher Summary This chapter discusses that the numeral VIII has been agreed upon internationally to designate clotting factor is missing from blood of hemophiliacs. The classical studies recessive, sex-linked disorder hemophilia provides evidence a gene concerned with synthesis situated on X-chromosome. When it was discovered reduction in commonly present also von Willebrand's disease, somatic dominant inheritance, became clear another gene, an autosome, must be involved. Cross-transfusion experiments between patients suffering and disease showed hemophilic would stimulate but not vice versa. These data have made possible construct number alternative genetic models now being submitted critical experimentation. Some progress mapping position locus