Phospholipid substitution of capsular (K) polysaccharide antigens from Escherichia coli causing extraintestinal infections
作者： M. Alexander Schmidt , K. Jann
DOI: 10.1111/J.1574-6968.1982.TB08637.X
关键词:
摘要: The capsular antigens of Escherichia coli causing extraintestinal infections have been analyzed extensively. K1 antigen which is identical with the Neisseria meningitidis B [1] has described by McGuire and Binkley [2] Orskov et al. [3]. We recently reported structures K2, K5, K12, K62 K82 ([4-7]; Schmidt, M.A. Jann, K., in preparation). During our study we found that these K antigens, are all acidic polysaccharides, tend to aggregate aqueous solutions. aggregation could be abolished Triton X-100, very mild acid hydrolysis treatment alkali. These results indicated polysaccharides contain a lipid moiety labile linkage. report here characterization polysaccharide analysis I2 antigens. was shown phosphatidic acid. preparation this manuscript similar studies were Gotschlich [8] concerning polyneuraminic also K92 E. coli. Our agreement those show termination phospholipid seems general structural feature. 2.1. Bacteria cultivation
oup.com
sci-hub.se 参考文章(15)
George R. Waller, Biochemical applications of mass spectrometry ,(1972)
Hans Ulrich Bergmeyer, Methoden der enzymatischen Analyse Chemie. ,(1962)
E C Gotschlich, B A Fraser, O Nishimura, J B Robbins, T Y Liu, Lipid on capsular polysaccharides of gram-negative bacteria. Journal of Biological Chemistry. ,vol. 256, pp. 8915- 8921 ,(1981) , 10.1016/S0021-9258(19)52486-3
K Jann, B Jann, M A Schmidt, W F Vann, Structure of the Escherichia coli K2 capsular antigen, a teichoic acid-like polymer. Journal of Bacteriology. ,vol. 143, pp. 1108- 1115 ,(1980) , 10.1128/JB.143.3.1108-1115.1980
A K Bhattacharjee, H J Jennings, C P Kenny, A Martin, I C Smith, Structural determination of the sialic acid polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance. Journal of Biological Chemistry. ,vol. 250, pp. 1926- 1932 ,(1975) , 10.1016/S0021-9258(19)41784-5
Frank M. Unger, The Chemistry and Biological Significance of 3-Deoxy-d-manno-2-Octulosonic Acid (KDO) Advances in Carbohydrate Chemistry and Biochemistry Volume 38. ,vol. 38, pp. 323- 388 ,(1981) , 10.1016/S0065-2318(08)60313-3
Structure and serological specificity of the K13-antigenic polysaccharide (K13 antigen) of urinary tract-infective Escherichia coli. Infection and Immunity. ,vol. 25, pp. 85- 92 ,(1979) , 10.1128/IAI.25.1.85-92.1979
H A McArthur, I C Hancock, J Baddiley, Attachment of the main chain to the linkage unit in biosynthesis of teichoic acids. Journal of Bacteriology. ,vol. 145, pp. 1222- 1231 ,(1981) , 10.1128/JB.145.3.1222-1231.1981
Willie F. VANN, M. Alexander SCHMIDT, Barbara JANN, Klaus JANN, The structure of the capsular polysaccharide (K5 antigen) of urinary-tract-infective Escherichia coli 010:K5:H4. A polymer similar to desulfo-heparin. FEBS Journal. ,vol. 116, pp. 359- 364 ,(1981) , 10.1111/J.1432-1033.1981.TB05343.X
Edward J. McGuire, Stephen B. Binkley, THE STRUCTURE AND CHEMISTRY OF COLOMINIC ACID. Biochemistry. ,vol. 3, pp. 247- 251 ,(1964) , 10.1021/BI00890A017