2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
作者： Yichao Wan , Jiabing Long , Han Gao , Zilong Tang
DOI: 10.1016/J.EJMECH.2020.112953
关键词:
摘要: … The docking study showed that the linear chain amide instead of l-prolinamide in alpelisib … inhibitory activity against human leukemia MV4-11 cells, with IC 50 values ranging from 2.17 …
sci-hub.st 参考文章(107)
Robin A. Fairhurst, Marc Gerspacher, Patricia Imbach-Weese, Robert Mah, Giorgio Caravatti, Pascal Furet, Christine Fritsch, Christian Schnell, Joachim Blanz, Francesca Blasco, Sandrine Desrayaud, Daniel A. Guthy, Mark Knapp, Dorothee Arz, Jasmin Wirth, Esther Roehn-Carnemolla, Van Huy Luu, Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 3575- 3581 ,(2015) , 10.1016/J.BMCL.2015.06.067
Robin A. Fairhurst, Patricia Imbach-Weese, Marc Gerspacher, Giorgio Caravatti, Pascal Furet, Thomas Zoller, Christine Fritsch, Dorothea Haasen, Joerg Trappe, Daniel A. Guthy, Dorothee Arz, Jasmin Wirth, Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 3569- 3574 ,(2015) , 10.1016/J.BMCL.2015.06.078
Markian M. Stec, Kristin L. Andrews, Yunxin Bo, Sean Caenepeel, Hongyu Liao, John McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subramanian, Nuria Tamayo, Douglas A. Whittington, Ling Wang, Tian Wu, Leeanne P. Zalameda, Nancy Zhang, Paul E. Hughes, Mark H. Norman, The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 4136- 4142 ,(2015) , 10.1016/J.BMCL.2015.08.016
Gayathri Chandrasekaran, Péter Tátrai, Fanni Gergely, Hitting the brakes: targeting microtubule motors in cancer. British Journal of Cancer. ,vol. 113, pp. 693- 698 ,(2015) , 10.1038/BJC.2015.264
Heike Lehrmann, Linda Louise Pritchard, Annick Harel-Bellan, Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation Advances in Cancer Research. ,vol. 86, pp. 41- 65 ,(2002) , 10.1016/S0065-230X(02)86002-X
Mark C. Bellingham, A Review of the Neural Mechanisms of Action and Clinical Efficiency of Riluzole in Treating Amyotrophic Lateral Sclerosis: What have we Learned in the Last Decade? CNS Neuroscience & Therapeutics. ,vol. 17, pp. 4- 31 ,(2011) , 10.1111/J.1755-5949.2009.00116.X
Cecilia L. Speyer, Ali H. Hachem, Ali A. Assi, Jennifer S. Johnson, John A. DeVries, David H. Gorski, Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer PLoS ONE. ,vol. 9, pp. e88830- ,(2014) , 10.1371/JOURNAL.PONE.0088830
Hwa Jin Lee, Brian A. Wall, Janet Wangari-Talbot, Seung-Shick Shin, Stephen Rosenberg, Joseph L-K. Chan, Jin Namkoong, James S. Goydos, Suzie Chen, Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies Clinical Cancer Research. ,vol. 17, pp. 7080- 7092 ,(2011) , 10.1158/1078-0432.CCR-11-0098
Carole Peyssonnaux, Alain Eychène, The Raf/MEK/ERK pathway: new concepts of activation Biology of the Cell. ,vol. 93, pp. 53- 62 ,(2001) , 10.1016/S0248-4900(01)01125-X
Brian A Wall, Lumeng J Yu, Atif Khan, Bruce Haffty, James S Goydos, Suzie Chen, None, Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells. Pigment Cell & Melanoma Research. ,vol. 28, pp. 105- 109 ,(2015) , 10.1111/PCMR.12327