Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development

摘要: Embryo quality during the in vitro developmental period is of great clinical importance. Experimental genetic studies this have demonstrated association between specific gene expression profiles and production healthy blastocysts. Although oocyte may play a major role embryo development, it has been well established that post - fertilization also an important crucial determination blastocyst quality. A variety genes (such as OCT, SOX2, NANOG) their related signaling pathways transcription molecules TGF-β, BMP) implicated pre- post-implantation period. Furthermore, DNA methylation lately characterized epigenetic mark since one most processes involved maintenance genome stability. Physiological development appears to depend upon correct pattern. Due fact soon after zygote undergoes several morphogenetic events including activation embryonic through transition maternal genome, diverse pattern lead clinically conditions, such apoptosis or chromosomically abnormal embryo. The present review focused on pre-implantation giving emphasis various parameters alter patterns. embryos derived from culture systems (in fertilization) possible effects prolonged conditions are discussed.