Stress-induced impairment of inhibitory avoidance learning in female neuromedin B receptor-deficient mice.

摘要: Neuromedin B (NMB) is a mammalian bombesin (BN)-like peptide that exerts its function via the neuromedin receptor (NMB-R). The NMB/NMB-R system involved in stress response, and therefore we examined behavioral properties female mice lacking NMB-R using restraint-induced paradigm. Thirty minutes of restraint wire mesh cage constituted sufficient stimulus for as evidenced by elevated blood glucose concentrations stressed wild-type NMB-R-deficient mice. Using one-trial passive avoidance test, exhibited marked reduction memory performance. spontaneous activity novel environment compared to non-stressed mutant after 30-min stress, similar difference was also observed between stressed/non-stressed An plus maze test showed had no effect on anxiety either or Furthermore, pain response induced electric foot shock not affected under conditions. These results indicate impaired performance consequence changes activity, anxiety, suggest pathway may play role regulating neural controls learning memory.