Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies.
作者： Stacy A. Castner , Li Xiao , Jill B. Becker
DOI: 10.1016/0006-8993(93)91225-H
关键词:
摘要: Experiments were conducted to examine sex differences in striatal dopamine function using vivo microdialysis freely moving rats. We report here a difference basal extracellular determined by quantitative (the no net flux method) when castrated and ovariectomized rats compared. There was uptake into synaptosomes. This indicates that the is most likely due release, synthesis, and/or metabolism. Within 30 min after single injection (s.c.) of either estradiol benzoate (2.0 ~tg/100 g) or 17/3-estradiol (1.5 ~g/100 amphetamine-stimulated release enhanced striatum rats, but there effect male The amphetamine-induced associated with an frequency stereotyped head limb movements increased peak extra 1/4 turns. also behavior turns whether not animals received estrogen treatment. Thus, are extraceUular on neurochemical behavioral responses amphetamine.
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