First Demonstration of Multiplexed X-Ray Fluorescence Computed Tomography (XFCT) Imaging
作者： Yu Kuang , Guillem Pratx , Magdalena Bazalova , Bowen Meng , Jianguo Qian
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摘要: Simultaneous imaging of multiple probes or biomarkers represents a critical step toward high specificity molecular imaging. In this work, we propose to utilize the element-specific nature of the X-ray fluorescence (XRF) signal for imaging multiple elements simultaneously (multiplexing) using XRF computed tomography (XFCT). A 5-mm-diameter pencil beam produced by a polychromatic X-ray source (150 kV, 20 mA) was used to stimulate emission of XRF photons from 2%(weight/volume) gold (Au), gadolinium (Gd), and barium (Ba) …
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