A microarray study to characterize the molecular mechanism of TIMP-3-mediated tumor rejection
作者： Paula Lam , Kar Sian Lim , Suk Mei Wang , Kam M Hui , None
DOI: 10.1016/J.YMTHE.2005.02.028
关键词:
摘要: Glial cell invasion is a multistep cellular process that involves complex system of tightly regulated proteases (matrix metalloproteinases; MMPs) and their endogenous inhibitors (tissue TIMPs) to mediate the degradation basement membrane extracellular matrix. Tissue inhibitor metalloproteinases-3 (TIMP-3) matrix-bound MMPs. In present study, we have overexpressed TIMP3 gene in human glioma cells with herpes simplex virus type 1 amplicon-based vector. Oligonucleotide DNA arrays were employed identify genes differentially modulated by overexpression TIMP-3. Consistent function TIMP-3, associated angiogenesis, growth factors, cytokines, death receptors, substrates various MMPs found be up-regulated. Furthermore, caspases are important signaling pathway apoptosis, TIMP-3 activation caspases, including caspase-1, at both mRNA level (P=0.0371) protein level. Moreover, an apoptotic via induced apoptosis transduced vitro inhibition tumor xenografts immunodeficient mice.
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