TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway.
作者： Janne P. Kallio , Sally Hopkins-Donaldson , Andrew H. Baker , Veli-Matti Kähäri
DOI: 10.1002/IJC.25404
关键词:
摘要: Tissue inhibitor of metalloproteinases-3 (TIMP-3) has previously been identified as a tumor suppressor for adherent malignant and normal cells. TIMP-3 inhibits adhesion cells to extracellular matrix promotes apoptosis through death receptor-activated, caspase-8-mediated pathway. Here, we have studied the effect adenovirally mediated overexpression on small cell lung cancer (SCLC) lines SW2 N417, which grow in suspension lack functional caspase-8. The results show that adenoviral delivery apoptotic SCLC absence caspase-8 activation. These suggest promising therapeutic anticancer protein also nonadherent lacking receptor signaling.
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