Recurrent Deletion of the Short Arm of Chromosome 3 in Human Renal Cell Carcinoma: Shift of the c-raf 1 Locus

摘要: A cytogenetic study performed on 6 human renal cell carcinomas after short-term culture extracellular matrix with serum-free medium showed aneuploidy without structural changes in 2 tumors and a rearrangement of the short arm chromosome 3 4 tumors, including deletions translocation involving 3p14 3p21 bands. Chromosomal situ hybridization c-raf 1 probe demonstrated that cancers del3(p14 or 21) cellular oncogene had shifted from 3p25 to as result an interstitial deletion.