Phase II drug metabolizing enzymes
作者： Petra Jancova , Pavel Anzenbacher , Eva Anzenbacherova
DOI: 10.5507/BP.2010.017
关键词:
摘要: Background. Phase II biotransformation reactions (also ‘conjugation reactions’) generally serve as a detoxifying step in drug metabolism. metabolising enzymes are mainly transferases. This review covers the major phase enzymes: UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases (mainly thiopurine S-methyl transferase catechol O-methyl transferase). The focus is on presence of various forms, tissue cellular distribution, respective substrates, genetic polymorphism finally interspecies differences these enzymes. Methods Results. A literature search using following databases PubMed, Science Direct EBSCO for years, 1969–2010. Conclusions. metabolizing play an important role endogenous compounds xenobiotics to more easily excretable forms well metabolic inactivation pharmacologically active compounds. Reduced capacity can lead toxic effects clinically used drugs. Gene polymorphism/ lack may often several cancer.
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