Chondroid Chordoma—A Variant of Chordoma: A Morphologic and Immunohistochemical Study

摘要: In 1973, Heffelfinger and coworkers described a variant of chordoma that contained cartilaginous areas indistinguishable from hyaline type chondrosarcoma. They designated these tumors chondroid chordomas found they had better prognosis than classic (nonchondroid) chordomas. Since time, there has been an ongoing debate over whether is best considered distinct clinicopathologic entity separable chondrosarcoma or misdiagnosed whose concept developed the erroneous interpretation morphology. attempt to clarify issue, authors used light microscopy immunohistochemistry study 12 chordomas, 38 28 chondrosarcomas arose in base skull spine. As reference, also analyzed immunohistochemical profile fetal notochord, ecchordosis physaliphora, cartilage. all nonchondroid were positive for cytokeratin, majority epithelial membrane antigen (EMA) carcinoembryonic (CEA). contrast, none stained EMA CEA. Vimentin S-100 more 95% both chondrosarcomas. The was similar pattern immunoreactivity their nonneoplastic counterparts. conclude should not be confused with Because have reported prognosis, felt this nosologic term preserved continue focus clinical pathologic study.