Effects of human interleukin-18 and interleukin-12 treatment on human lymphocyte engraftment in NOD-scid mouse.
作者： Hidenobu Senpuku , Toshihiko Asano , Khairul Matin , M. Abdus Salam , YUZO Tsuha
DOI: 10.1046/J.1365-2567.2002.01484.X
关键词:
摘要: NOD/LtSz-prkdc(scid)/prkdc(scid) (non-obese diabetic-severe combine immunodeficiency; NOD-scid) mice grafted with human peripheral blood lymphoid cells have been used as an in vivo humanized mouse model various studies. However, cytotoxic T are induced this during immune responses, which gives misleading results. To assist grafting of lymphocytes without the induction cells, we investigated effects helper type 1 (Th1) and Th2 cytokines on lymphocyte migration, well production immunoglobulin deposited glomeruli immunodeficiency virus-1 (HIV-1) infection using NOD-scid mice. Administration interleukin-18 (IL-18) IL-12 enhanced CD4+ CD8+ mice, whereas co-administration prevented due to interferon-gamma-dependent apoptosis. Immunoglobulin A (IgA) deposits were observed treated IL-18 alone, but not those given phosphate-buffered saline, or + IL-12. high rate HIV was also IL-18-treated group. Together, these results indicate that may be effective for migration except apoptosis regulation class-switching IgA. IL-18-administered provide a useful small study IgA nephropathy.
sci-hub.se 参考文章(40)
Avichai Shimoni, Hadar Marcus, Allon Canaan, David Ergas, Magda David, Alain Berrebi, Yair Reisner, A Model for Human B-Chronic Lymphocytic Leukemia in Human/Mouse Radiation Chimera: Evidence for Tumor-Mediated Suppression of Antibody Production in Low-Stage Disease Blood. ,vol. 89, pp. 2210- 2218 ,(1997) , 10.1182/BLOOD.V89.6.2210
J Kataoka, K Kohno, M Kurimoto, M Ikeda, M Usui, I Okamoto, Y Suemoto, T Ohtsuki, IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. Journal of Immunology. ,vol. 158, pp. 1541- 1550 ,(1997)
Tomohiro Yoshimoto, Hitoshi Mizutani, Hiroko Tsutsui, Nancy Noben-Trauth, Kei-ichi Yamanaka, Minoru Tanaka, Shinzo Izumi, Haruki Okamura, William E. Paul, Kenji Nakanishi, IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nature Immunology. ,vol. 1, pp. 132- 137 ,(2000) , 10.1038/77811
Stephen C. Pelsue, Jean H. Leif, Kathryn L. Shultz, Dale L. Greiner, RuthAnn M. Hesselton, Leonard D. Shultz, Isabelle Schweitzer, Jon Yates, Wes G. Beamer, Michael C. Appel, George Perdrizet, Thiruchandurai V. Rajan, Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. American Journal of Pathology. ,vol. 146, pp. 888- 902 ,(1995)
I B Schweitzer, B Tennent, S McKenna, L Mobraaten, P A Schweitzer, B Gott, S W Christianson, D L Greiner, T V Rajan, L D Shultz, Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. Journal of Immunology. ,vol. 154, pp. 180- 191 ,(1995)
Jonathan W. Uhr, J. David Farrar, Richard H. Scheuermann, Nancy E. Street, Jana Windsor, Gerald Thrush, Kathy H. Katz, Cancer Dormancy. VII. A Regulatory Role for CD8+ T Cells and IFN-γ in Establishing and Maintaining the Tumor-Dormant State Journal of Immunology. ,vol. 162, pp. 2842- 2849 ,(1999)
M Kurimoto, T Tanimoto, M Ikeda, K Konishi, K Hattori, Y Nukada, K Torigoe, T Okura, S Fukuda, M Fujii, K Akita, S Ushio, F Tanabe, M Namba, M Micallef, H Okamura, Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. Journal of Immunology. ,vol. 156, pp. 4274- 4279 ,(1996)
Keizo Kohno, Masashi Kurimoto, Tadao Tanimoto, Hakuo Ikegami, Iwao Okamoto, Development of CD8+ Effector T Cells Is Differentially Regulated by IL-18 and IL-12 Journal of Immunology. ,vol. 162, pp. 3202- 3211 ,(1999)
K Hiroishi, H Okamura, T Yoshimoto, K Nakanishi, Y Hyodo, H Tsutsui, K Higashino, N Hayashi, K Matsui, N Kawada, Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells. Journal of Immunology. ,vol. 159, pp. 97- 106 ,(1997)
Nagaradona Harindranath, Hong Zan, Andras Schaffer, Leif Bergsagel, Andrea Cerutti, Paolo Casali, Edward E. Max, CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line Journal of Immunology. ,vol. 160, pp. 2145- 2157 ,(1998)