The Effect of Nimodipine, a Centrally Active Calcium Antagonist, on Visual Function and Macular Blood Flow in Patients with Normal-tension Glaucoma and Control Subjects

摘要: Purpose This study was performed to evaluate the effect of nimodipinc, a centrally active calcium channel antagonist on automated Humphrey visual fields, Farnsworth-Munsell 100 (FM-100) hue color vision testing, and macular blood flow (blue field entoptic simulation technique) in patients with normal-tension glaucoma (NTG) control subjects. Methods Thirteen NTG thirteen age-and sex-matched subjects were studied prospective, placebo-controlled, double-masked, crossover protocol. On each two dates, testing at baseline 90 minutes after administration either 30-mg nimodipinc capsules or identical appearing placebo capsules. Blood pressure pulse monitored throughout study. Results Nimodipinc resulted performance corrected improvement mean deviation (patients subjects), pattern standard NTG), sensitivity (the average foveal threshold four most central points field; NTG). The FM-100 error scores significantly decreased nimodipine compared baseline. There no significant differences leukocyte velocity density between subjects; changes noted group. Conclusion Nimodipine caused vision. did not alter hemodynamics as measured using blue technique, although results hampered by high variability, particularly measurements.